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Medicines (Draft)


Indications for Using Cialis

Cialis is a modern drug from the group of PDE-5 inhibitors. The main indication for the use of Cialis is a persistent violation of potency, when a man cannot achieve or maintain an erection sufficient for a normal sexual intercourse – erectile dysfunction (ED), colloquially often referred to as impotence. According to the official classification, Cialis is used in case of insufficiency of the genital reaction (psychogenic impotence), as well as impotence of organic origin. In fact, Cialis demonstrates efficacy against erectile dysfunction of organic, psychological, and combined etiology. Most often, erectile dysfunction is of a combined etiology, since physical violations of potency lead to the development of psychological problems, and self-doubt and increased nervousness lead to physical violations of potency.

FDA (Food and Drug Administration) approved Cialis for the treatment of erectile dysfunction in 2003, and in 2012 it was also approved as a treatment for benign prostatic hyperplasia. In the treatment of BPH, Cialis is used both as monotherapy and as part of a combination treatment.

Composition of Cialis

Cialis contains one active ingredient – Tadalafil, a reversible selective inhibitor of the PDE-5 enzyme. It is noteworthy that Tadalafil affects the male body only when there is sexual arousal or sexual stimulation. Only in this case, a local release of nitric oxide occurs, which makes it possible for the onset of action of Tadalafil. By inhibiting the enzyme PDE-5 (phosphodiesterase type 5), Tadalafil increases the level of cGMP in the cavernous body of the penis. As a result, relaxation of the smooth muscles of the arteries is observed, and the vasodilating effect of Tadalafil stimulates blood flow to the tissues of the penis. This facilitates the onset of an erection, which becomes and causes an erection. In the absence of sexual stimulation or erotic mood, Cialis is ineffective and cannot cause an erection, since it does not affect the libido and hormonal levels of the body. Tadalafil is not an aphrodisiac or a narcotic substance and doesn’t cause any physical or psychological addiction, regardless of the frequency of use.

Naturally, in addition to the main ingredient, Cialis also contains auxiliary substances that form the film shell of the tablet, form its mass and help to ensure that it is sufficiently strong. These include lactose monohydrate, hyprolose, microcrystalline cellulose, magnesium stearate, dye and some other elements. They don’t affect the action of the drug.

How To Take Cialis?

Cialis is available to consumers in the form of pills for oral administration with a dosage of 5, 10 and 20 mg of Tadalafil in one pill. The dosage for each patient and the treatment scheme should be selected individually, depending on the age of the man, the severity of erectile dysfunction, as well as its etiology and the presence of concomitant diseases.

With severe violations of potency, for middle-aged and elderly men it is recommended to take Cialis at a dosage of 20 mg on demand, that is, if it is planned to have sexual intercourse in the near future. The optimal time of admission is 20-40 minutes before the expected sexual activity, since this time span is needed in order for Tadalafil to be absorbed and start acting. However, Cialis is famous for its long-lasting effect: after taking a dosage of 20 mg, the drug remains in the system for up to 36 hours, and a man can attempt sexual intercourse as many times as he likes during this time. All organisms are individual; therefore, not all men have the same reaction time to Cialis, as well as its total duration. It may take several doses of medication in order to understand with what degree of severity Cialis acts specifically in your case. If the pill doesn’t last as long as a day and a half, you can repeat the dose the next day. However, no matter what dosage you are taking, you cannot do this more often than once a day. If necessary, increase the dosage, you can take not 5, but 10 or 20 mg of Tadalafil the next day.

For young men who have mild or moderate symptoms of erectile dysfunction, it is optimal to take Cialis at a dosage of 10 mg on demand. If it is known that the cause of failure in bed is psychological problems, such as bad sexual experience, self-doubt, a new partner, 5 mg of Tadalafil may be enough to normalize an erection.

When using Cialis in the treatment of benign prostatic hyperplasia (BPH), as a rule, urologists prescribe this medication to be taken on a daily basis in a small dosage. Depending on the degree of prostate enlargement and whether Cialis is the only agent used to reduce the volume of the prostate, or a combination treatment regimen is used, doctors recommend taking 5 or 2.5 mg of Tadalafil every day. In addition, to maintain approximately the same concentration, it is better to take Cialis at the same time of day. A feature of Cialis, which distinguishes it from all other drugs against erectile dysfunction from the group of PDE-5 inhibitors, is that its absorption into the blood and, accordingly, its effectiveness is not affected by the amount of food eaten. Thus, Cialis can be taken at any convenient time, and not necessarily on an empty stomach, and the patient doesn’t have to be afraid that his body won’t be able to absorb it.

Before taking Cialis, it is strongly recommended to carefully study the instructions for use. The main contraindications to the use of Cialis are associated with severe cardiovascular diseases, as well as severe renal failure. It is not advised to take Tadalafil for men who, because of severe pathologies of the cardiovascular system, are better off avoiding sexual activity. Partial contraindications for taking Cialis include conditions such as a predisposition to priapism (which can be observed in sickle cell anemia, multiple myeloma and leukemia), as well as the presence of anatomical deformities of the penis (because of trauma, angulation, cavernous fibrosis, Peyronie’s disease).

Cialis is contraindicated to be taken in combination with medications that contain nitrates. It is also not recommended to combine Cialis with other remedies against erectile dysfunction, especially from the category of PDE-5 inhibitors.

How To Buy Cialis with Maximum Benefit?

Faced with such an unpleasant disease as erectile dysfunction, first of all, any man seeks to effectively improve his potency. Problem number two is that you need to achieve this without going broke. Meanwhile, prices for erectile dysfunction products are traditionally among the highest. Nevertheless, there are several ways to significantly save money when buying Cialis, so that there is no need to lament the money spent and spoil your pleasure from your sex life.

In general, in the modern pharmaceutical market, the most profitable way to buy Cialis is to place an order in an online pharmacy. Such pharmacies work with large suppliers of Cialis and save a lot of money due to the fact that they don’t spend on sales areas, but only support warehouses from which medicines are delivered by mail and courier services to their destinations. To buy branded Cialis in an online pharmacy that operates in the United States, you will need to have a prescription from a doctor, a scan of which, most likely, you will be asked to send to the manager before placing an order. It should be noted that a prescription is also required to reimburse the drug through health insurance.
It is easier to buy Cialis without a prescription if the consumer chooses the generic version, but this is also possible in the case of a branded drug. For purchasing branded Cialis over the counter, the easiest way is to place an order at an international or foreign online pharmacy, whose activities are not regulated by US pharmaceutical legislation. You should not be afraid to make such purchases, because US laws in no way prohibit citizens from buying medicines abroad if they are not included in the list of prohibited substances.

Manufacturers And Suppliers

First of all, it should be noted that Cialis is of two types: original (brand) and generic. The manufacturer of the branded Cialis is the US pharmaceutical giant Eli Lilly, headquartered in Indianapolis. It is this manufacturer that supplies the global pharmaceutical market with oval dark yellow tablets under the trade name Cialis, which is a registered trademark. Generic Cialis is represented by a large number of very different trade names, for example, Tadalafil, Tadalista, Tadalis, Vidalista, Tadarise, Tadasoft, etc. They are produced by almost all major pharmaceutical companies around the world. The palm in the market for Cialis generics belongs to Indian medicines. They are manufactured by companies such as Sunrise Remedies, Centurion Laboratories, Fortune Health Care, Ajanta Pharma and many others: Torrent Pharma, Camber Pharmaceuticals, Dr. Reddy’s Laboratories. Their number is not limited to this list, but these are among the companies with the best reputation.

Cialis Prices

Cialis has established itself as the most effective drug for eliminating the symptoms of erectile dysfunction and normalizing blood circulation in the small pelvis, which is well tolerated by the body. Unlike other PDE-5 inhibitors, Cialis seldom causes severe side effects. However, the widespread use of the branded drug is hindered by the fact that it costs, to put it mildly, not cheap at all. The average price of one tablet with a dosage of 20 mg or 10 mg is $70, 5 mg – $15. Since you can take Cialis at least every day, if there is a need for it, the cost of a monthly course of treatment for erectile dysfunction can cost the patient about $700. Even in the treatment of BPH, when 5 mg of Tadalafil per day is enough, the patient has to spend about $200 per month.

Among consumers in the United States, Canadian suppliers of Cialis generics are very popular, the largest of which is Apotex. The range of dosages and forms of release from Canadian pharmaceutical companies is not very large, but they are famous for the high quality of their products.

Generics of Cialis are available in a wide variety of dosage forms and dosages, but they are all significantly cheaper than the branded medicine. Choosing one of generic versions of Cialis means saving up to 90% of the cost of the original drug. Nevertheless, the range of prices for generics is quite large. Cialis from European manufacturers costs an average of about $30 per a 20 mg pill, while Indian and Malay generics are quite realistic to purchase at a price of $1-2 per pill.

Discounts And Rebates

Cialis is usually present in the assortment of most major online pharmacies, and many of them from time to time offer remarkable discounts on this drug and its generics. Sometimes they are timed to coincide with holidays such as Christmas or Valentine’s Day, sometimes they are held just like that. It is most convenient to follow the appearance of the most profitable offers, either by subscribing to the newsletter of a particular pharmacy that suits you best, or using special sites – aggregators of special offers and discounts. They are convenient in that they display information about promotions in many pharmacies. With their help, you can get a promotional code or a discount coupon, often of limited validity, and use it, saving up to 50% extra on the purchase price.

Special attention should be paid to such a moment as loyalty points (bonus points). If you regularly shop at the same pharmacy, you usually earn bonus points that you can spend on subsequent purchases. More favorable delivery terms are also available to regular customers. Sometimes consumers receive special offers for participating in pharmacy surveys and customer opinion surveys.

Profitable Purchase Options

If you have made the decision to buy Cialis from an online pharmacy, the best option is Indian generics from major manufacturers. When ordering Cialis in Indian pharmacies, you get a quality medicine that meets all international pharmaceutical standards at a ridiculous price compared to a branded medicine. Although the delivery of medicines from India to the United States is not very fast, its price is very democratic, and this cost item will not hit your pocket hard.

However, there is a nuance here. It is most profitable to buy Cialis from India if you take it on a more or less constant basis, since the prices for this medicine are the lowest if you place an order for a large number of pills at once. This is the situation with all generic erectile dysfunction drugs. The cheapest offers start when you order from 60 pills, and if you buy 100 pieces at once, then the prices will be reduced as much as possible. If you are just starting your acquaintance with drugs against ED, then it may be more appropriate to buy one or two Cialis pills at a local pharmacy or in an online pharmacy based in the United States to test how they work on you, all the more this will help to save on delivery.